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Nerium International is a consumer products company that offers skin care products, discovered that the unique properties of the Nerium oleander plant provided remarkable age-defying results when applied to the skin, patented an extraction process to create a Nerium oleander extract product called NAE-8. Nerium. to develop, formulate and manufacture natural skincare products, some of which would contain the NAE-8 extract. Having developed a first-of-its-kind products.